diff --git a/discovery/kubernetes/endpoints.go b/discovery/kubernetes/endpoints.go
index d8c9689ca..c7a60ae6d 100644
--- a/discovery/kubernetes/endpoints.go
+++ b/discovery/kubernetes/endpoints.go
@@ -62,6 +62,8 @@ func NewEndpoints(l log.Logger, eps cache.SharedIndexInformer, svc, pod, node ca
 	svcUpdateCount := eventCount.WithLabelValues(RoleService.String(), MetricLabelRoleUpdate)
 	svcDeleteCount := eventCount.WithLabelValues(RoleService.String(), MetricLabelRoleDelete)
 
+	podUpdateCount := eventCount.WithLabelValues(RolePod.String(), MetricLabelRoleUpdate)
+
 	e := &Endpoints{
 		logger:           l,
 		endpointsInf:     eps,
@@ -131,6 +133,29 @@ func NewEndpoints(l log.Logger, eps cache.SharedIndexInformer, svc, pod, node ca
 	if err != nil {
 		level.Error(l).Log("msg", "Error adding services event handler.", "err", err)
 	}
+	_, err = e.podInf.AddEventHandler(cache.ResourceEventHandlerFuncs{
+		UpdateFunc: func(old, cur interface{}) {
+			podUpdateCount.Inc()
+			oldPod, ok := old.(*apiv1.Pod)
+			if !ok {
+				return
+			}
+
+			curPod, ok := cur.(*apiv1.Pod)
+			if !ok {
+				return
+			}
+
+			// the Pod's phase may change without triggering an update on the Endpoints/Service.
+			// https://github.com/prometheus/prometheus/issues/11305.
+			if curPod.Status.Phase != oldPod.Status.Phase {
+				e.enqueuePod(namespacedName(curPod.Namespace, curPod.Name))
+			}
+		},
+	})
+	if err != nil {
+		level.Error(l).Log("msg", "Error adding pods event handler.", "err", err)
+	}
 	if e.withNodeMetadata {
 		_, err = e.nodeInf.AddEventHandler(cache.ResourceEventHandlerFuncs{
 			AddFunc: func(o interface{}) {
@@ -166,6 +191,18 @@ func (e *Endpoints) enqueueNode(nodeName string) {
 	}
 }
 
+func (e *Endpoints) enqueuePod(podNamespacedName string) {
+	endpoints, err := e.endpointsInf.GetIndexer().ByIndex(podIndex, podNamespacedName)
+	if err != nil {
+		level.Error(e.logger).Log("msg", "Error getting endpoints for pod", "pod", podNamespacedName, "err", err)
+		return
+	}
+
+	for _, endpoint := range endpoints {
+		e.enqueue(endpoint)
+	}
+}
+
 func (e *Endpoints) enqueue(obj interface{}) {
 	key, err := cache.DeletionHandlingMetaNamespaceKeyFunc(obj)
 	if err != nil {
@@ -312,7 +349,7 @@ func (e *Endpoints) buildEndpoints(eps *apiv1.Endpoints) *targetgroup.Group {
 			tg.Targets = append(tg.Targets, target)
 			return
 		}
-		s := pod.Namespace + "/" + pod.Name
+		s := namespacedName(pod.Namespace, pod.Name)
 
 		sp, ok := seenPods[s]
 		if !ok {
diff --git a/discovery/kubernetes/endpoints_test.go b/discovery/kubernetes/endpoints_test.go
index cf7fd9aee..e877657db 100644
--- a/discovery/kubernetes/endpoints_test.go
+++ b/discovery/kubernetes/endpoints_test.go
@@ -969,3 +969,123 @@ func TestEndpointsDiscoveryEmptyPodStatus(t *testing.T) {
 		expectedRes:      map[string]*targetgroup.Group{},
 	}.Run(t)
 }
+
+// TestEndpointsUpdatePod makes sure that Endpoints discovery detects underlying Pods changes.
+// See https://github.com/prometheus/prometheus/issues/11305 for more details.
+func TestEndpointsDiscoveryUpdatePod(t *testing.T) {
+	pod := &v1.Pod{
+		ObjectMeta: metav1.ObjectMeta{
+			Name:      "testpod",
+			Namespace: "default",
+			UID:       types.UID("deadbeef"),
+		},
+		Spec: v1.PodSpec{
+			NodeName: "testnode",
+			Containers: []v1.Container{
+				{
+					Name:  "c1",
+					Image: "c1:latest",
+					Ports: []v1.ContainerPort{
+						{
+							Name:          "mainport",
+							ContainerPort: 9000,
+							Protocol:      v1.ProtocolTCP,
+						},
+					},
+				},
+			},
+		},
+		Status: v1.PodStatus{
+			// Pod is in Pending phase when discovered for first time.
+			Phase: "Pending",
+			Conditions: []v1.PodCondition{
+				{
+					Type:   v1.PodReady,
+					Status: v1.ConditionFalse,
+				},
+			},
+			HostIP: "2.3.4.5",
+			PodIP:  "4.3.2.1",
+		},
+	}
+	objs := []runtime.Object{
+		&v1.Endpoints{
+			ObjectMeta: metav1.ObjectMeta{
+				Name:      "testendpoints",
+				Namespace: "default",
+			},
+			Subsets: []v1.EndpointSubset{
+				{
+					Addresses: []v1.EndpointAddress{
+						{
+							IP: "4.3.2.1",
+							// The Pending Pod may be included because the Endpoints was created manually.
+							// Or because the corresponding service has ".spec.publishNotReadyAddresses: true".
+							TargetRef: &v1.ObjectReference{
+								Kind:      "Pod",
+								Name:      "testpod",
+								Namespace: "default",
+							},
+						},
+					},
+					Ports: []v1.EndpointPort{
+						{
+							Name:     "mainport",
+							Port:     9000,
+							Protocol: v1.ProtocolTCP,
+						},
+					},
+				},
+			},
+		},
+		pod,
+	}
+	n, c := makeDiscovery(RoleEndpoint, NamespaceDiscovery{}, objs...)
+
+	k8sDiscoveryTest{
+		discovery: n,
+		afterStart: func() {
+			// the Pod becomes Ready.
+			pod.Status.Phase = "Running"
+			pod.Status.Conditions = []v1.PodCondition{
+				{
+					Type:   v1.PodReady,
+					Status: v1.ConditionTrue,
+				},
+			}
+			c.CoreV1().Pods(pod.Namespace).Update(context.Background(), pod, metav1.UpdateOptions{})
+		},
+		expectedMaxItems: 2,
+		expectedRes: map[string]*targetgroup.Group{
+			"endpoints/default/testendpoints": {
+				Targets: []model.LabelSet{
+					{
+						"__address__":                                    "4.3.2.1:9000",
+						"__meta_kubernetes_endpoint_port_name":           "mainport",
+						"__meta_kubernetes_endpoint_port_protocol":       "TCP",
+						"__meta_kubernetes_endpoint_ready":               "true",
+						"__meta_kubernetes_endpoint_address_target_kind": "Pod",
+						"__meta_kubernetes_endpoint_address_target_name": "testpod",
+						"__meta_kubernetes_pod_name":                     "testpod",
+						"__meta_kubernetes_pod_ip":                       "4.3.2.1",
+						"__meta_kubernetes_pod_ready":                    "true",
+						"__meta_kubernetes_pod_phase":                    "Running",
+						"__meta_kubernetes_pod_node_name":                "testnode",
+						"__meta_kubernetes_pod_host_ip":                  "2.3.4.5",
+						"__meta_kubernetes_pod_container_name":           "c1",
+						"__meta_kubernetes_pod_container_image":          "c1:latest",
+						"__meta_kubernetes_pod_container_port_name":      "mainport",
+						"__meta_kubernetes_pod_container_port_number":    "9000",
+						"__meta_kubernetes_pod_container_port_protocol":  "TCP",
+						"__meta_kubernetes_pod_uid":                      "deadbeef",
+					},
+				},
+				Labels: model.LabelSet{
+					"__meta_kubernetes_namespace":      "default",
+					"__meta_kubernetes_endpoints_name": "testendpoints",
+				},
+				Source: "endpoints/default/testendpoints",
+			},
+		},
+	}.Run(t)
+}
diff --git a/discovery/kubernetes/endpointslice.go b/discovery/kubernetes/endpointslice.go
index f977ce262..116f02076 100644
--- a/discovery/kubernetes/endpointslice.go
+++ b/discovery/kubernetes/endpointslice.go
@@ -358,7 +358,7 @@ func (e *EndpointSlice) buildEndpointSlice(eps endpointSliceAdaptor) *targetgrou
 			tg.Targets = append(tg.Targets, target)
 			return
 		}
-		s := pod.Namespace + "/" + pod.Name
+		s := namespacedName(pod.Namespace, pod.Name)
 
 		sp, ok := seenPods[s]
 		if !ok {
diff --git a/discovery/kubernetes/kubernetes.go b/discovery/kubernetes/kubernetes.go
index 362e05326..489365fa4 100644
--- a/discovery/kubernetes/kubernetes.go
+++ b/discovery/kubernetes/kubernetes.go
@@ -767,6 +767,21 @@ func (d *Discovery) newPodsByNodeInformer(plw *cache.ListWatch) cache.SharedInde
 
 func (d *Discovery) newEndpointsByNodeInformer(plw *cache.ListWatch) cache.SharedIndexInformer {
 	indexers := make(map[string]cache.IndexFunc)
+	indexers[podIndex] = func(obj interface{}) ([]string, error) {
+		e, ok := obj.(*apiv1.Endpoints)
+		if !ok {
+			return nil, fmt.Errorf("object is not endpoints")
+		}
+		var pods []string
+		for _, target := range e.Subsets {
+			for _, addr := range target.Addresses {
+				if addr.TargetRef != nil && addr.TargetRef.Kind == "Pod" {
+					pods = append(pods, namespacedName(addr.TargetRef.Namespace, addr.TargetRef.Name))
+				}
+			}
+		}
+		return pods, nil
+	}
 	if !d.attachMetadata.Node {
 		return cache.NewSharedIndexInformer(plw, &apiv1.Endpoints{}, resyncDisabled, indexers)
 	}
@@ -872,3 +887,7 @@ func addObjectMetaLabels(labelSet model.LabelSet, objectMeta metav1.ObjectMeta,
 		labelSet[model.LabelName(metaLabelPrefix+string(role)+"_annotationpresent_"+ln)] = presentValue
 	}
 }
+
+func namespacedName(namespace, name string) string {
+	return namespace + "/" + name
+}
diff --git a/discovery/kubernetes/pod.go b/discovery/kubernetes/pod.go
index 615717c13..02990e415 100644
--- a/discovery/kubernetes/pod.go
+++ b/discovery/kubernetes/pod.go
@@ -33,7 +33,10 @@ import (
 	"github.com/prometheus/prometheus/discovery/targetgroup"
 )
 
-const nodeIndex = "node"
+const (
+	nodeIndex = "node"
+	podIndex  = "pod"
+)
 
 // Pod discovers new pod targets.
 type Pod struct {
@@ -326,7 +329,7 @@ func podSource(pod *apiv1.Pod) string {
 }
 
 func podSourceFromNamespaceAndName(namespace, name string) string {
-	return "pod/" + namespace + "/" + name
+	return "pod/" + namespacedName(namespace, name)
 }
 
 func podReady(pod *apiv1.Pod) model.LabelValue {