diff --git a/api/http/handler/users/user_delete.go b/api/http/handler/users/user_delete.go
index df72fe673..e192cd055 100644
--- a/api/http/handler/users/user_delete.go
+++ b/api/http/handler/users/user_delete.go
@@ -1,6 +1,7 @@
 package users
 
 import (
+	"errors"
 	"net/http"
 
 	httperror "github.com/portainer/libhttp/error"
@@ -17,6 +18,10 @@ func (handler *Handler) userDelete(w http.ResponseWriter, r *http.Request) *http
 		return &httperror.HandlerError{http.StatusBadRequest, "Invalid user identifier route variable", err}
 	}
 
+	if userID == 1 {
+		return &httperror.HandlerError{http.StatusForbidden, "Cannot remove the initial admin account", errors.New("Cannot remove the initial admin account")}
+	}
+
 	tokenData, err := security.RetrieveTokenData(r)
 	if err != nil {
 		return &httperror.HandlerError{http.StatusInternalServerError, "Unable to retrieve user authentication token", err}
diff --git a/app/portainer/components/datatables/users-datatable/usersDatatable.html b/app/portainer/components/datatables/users-datatable/usersDatatable.html
index 188dc0ba7..06e5f99cd 100644
--- a/app/portainer/components/datatables/users-datatable/usersDatatable.html
+++ b/app/portainer/components/datatables/users-datatable/usersDatatable.html
@@ -58,7 +58,7 @@
             >
               <td>
                 <span class="md-checkbox">
-                  <input id="select_{{ $index }}" type="checkbox" ng-model="item.Checked" ng-click="$ctrl.selectItem(item, $event)" />
+                  <input id="select_{{ $index }}" type="checkbox" ng-model="item.Checked" ng-click="$ctrl.selectItem(item, $event)" ng-disabled="!$ctrl.allowSelection(item)" />
                   <label for="select_{{ $index }}"></label>
                 </span>
                 <a ui-sref="portainer.users.user({id: item.Id})">{{ item.Username }}</a>
diff --git a/app/portainer/components/datatables/users-datatable/usersDatatable.js b/app/portainer/components/datatables/users-datatable/usersDatatable.js
index a3d38637e..258595c80 100644
--- a/app/portainer/components/datatables/users-datatable/usersDatatable.js
+++ b/app/portainer/components/datatables/users-datatable/usersDatatable.js
@@ -1,6 +1,9 @@
+import angular from 'angular';
+import UsersDatatableController from './usersDatatableController';
+
 angular.module('portainer.app').component('usersDatatable', {
   templateUrl: './usersDatatable.html',
-  controller: 'GenericDatatableController',
+  controller: UsersDatatableController,
   bindings: {
     titleText: '@',
     titleIcon: '@',
diff --git a/app/portainer/components/datatables/users-datatable/usersDatatableController.js b/app/portainer/components/datatables/users-datatable/usersDatatableController.js
new file mode 100644
index 000000000..8b8a60605
--- /dev/null
+++ b/app/portainer/components/datatables/users-datatable/usersDatatableController.js
@@ -0,0 +1,15 @@
+export default class UsersDatatableController {
+  /* @ngInject*/
+  constructor($controller, $scope) {
+    const allowSelection = this.allowSelection;
+    angular.extend(this, $controller('GenericDatatableController', { $scope }));
+    this.allowSelection = allowSelection.bind(this);
+  }
+
+  /**
+   * Override this method to allow/deny selection
+   */
+  allowSelection(item) {
+    return item.Id !== 1;
+  }
+}
diff --git a/app/portainer/views/users/edit/user.html b/app/portainer/views/users/edit/user.html
index bfc01dca4..f8b339336 100644
--- a/app/portainer/views/users/edit/user.html
+++ b/app/portainer/views/users/edit/user.html
@@ -34,7 +34,9 @@
           <div class="form-group">
             <div class="col-sm-4">
               <button class="btn btn-primary btn-sm" ng-disabled="!isSubmitEnabled()" ng-click="updateUser()">Save</button>
-              <button class="btn btn-danger btn-sm" ng-click="deleteUser()"><i class="fa fa-trash-alt space-right" aria-hidden="true"></i>Delete this user</button>
+              <button class="btn btn-danger btn-sm" ng-disabled="isDeleteDisabled()" ng-click="deleteUser()"
+                ><i class="fa fa-trash-alt space-right" aria-hidden="true"></i>Delete this user</button
+              >
             </div>
           </div>
         </form>
diff --git a/app/portainer/views/users/edit/userController.js b/app/portainer/views/users/edit/userController.js
index 93b3e6d9d..12aead65d 100644
--- a/app/portainer/views/users/edit/userController.js
+++ b/app/portainer/views/users/edit/userController.js
@@ -91,6 +91,12 @@ angular.module('portainer.app').controller('UserController', [
       return user && (user.Username !== formValues.username || (formValues.Administrator && user.Role !== 1) || (!formValues.Administrator && user.Role === 1));
     }
 
+    $scope.isDeleteDisabled = isDeleteDisabled;
+    function isDeleteDisabled() {
+      const { user } = $scope;
+      return user && user.Id === 1;
+    }
+
     function initView() {
       $scope.isAdmin = Authentication.isAdmin();