diff --git a/app/kubernetes/components/kubernetes-configuration-data/kubernetesConfigurationData.html b/app/kubernetes/components/kubernetes-configuration-data/kubernetesConfigurationData.html
index 432b524ee..59d5c39e4 100644
--- a/app/kubernetes/components/kubernetes-configuration-data/kubernetesConfigurationData.html
+++ b/app/kubernetes/components/kubernetes-configuration-data/kubernetesConfigurationData.html
@@ -45,8 +45,9 @@
           id="configuration_data_key_{{ index }}"
           name="configuration_data_key_{{ index }}"
           ng-model="$ctrl.formValues.Data[index].Key"
+          ng-disabled="entry.Used"
           required
-          ng-change="$ctrl.onChangeKey()"
+          ng-change="$ctrl.onChangeKey(entry)"
         />
       </div>
       <div
@@ -90,9 +91,13 @@
     <div class="form-group" ng-if="$ctrl.formValues.IsSimple">
       <div class="col-sm-1"></div>
       <div class="col-sm-11">
-        <button type="button" class="btn btn-sm btn-danger" style="margin-left: 0;" ng-click="$ctrl.removeEntry(index)">
+        <button type="button" class="btn btn-sm btn-danger space-right" style="margin-left: 0;" ng-disabled="entry.Used" ng-click="$ctrl.removeEntry(index, entry)">
           <i class="fa fa-trash-alt" aria-hidden="true"></i> Remove entry
         </button>
+        <span class="small text-muted" ng-if="entry.Used">
+          <i class="fa fa-info-circle blue-icon space-right" aria-hidden="true"></i>
+          This key is currently used by one or more applications
+        </span>
       </div>
     </div>
   </div>
diff --git a/app/kubernetes/components/kubernetes-configuration-data/kubernetesConfigurationDataController.js b/app/kubernetes/components/kubernetes-configuration-data/kubernetesConfigurationDataController.js
index 49d44307f..09658cf23 100644
--- a/app/kubernetes/components/kubernetes-configuration-data/kubernetesConfigurationDataController.js
+++ b/app/kubernetes/components/kubernetes-configuration-data/kubernetesConfigurationDataController.js
@@ -19,7 +19,11 @@ class KubernetesConfigurationDataController {
     this.showAdvancedMode = this.showAdvancedMode.bind(this);
   }
 
-  onChangeKey() {
+  onChangeKey(entry) {
+    if (entry.Used) {
+      return;
+    }
+
     this.state.duplicateKeys = KubernetesFormValidationHelper.getDuplicates(_.map(this.formValues.Data, (data) => data.Key));
     this.isValid = Object.keys(this.state.duplicateKeys).length === 0;
   }
@@ -28,7 +32,11 @@ class KubernetesConfigurationDataController {
     this.formValues.Data.push(new KubernetesConfigurationFormValuesEntry());
   }
 
-  removeEntry(index) {
+  removeEntry(index, entry) {
+    if (entry.Used) {
+      return;
+    }
+
     this.formValues.Data.splice(index, 1);
     this.onChangeKey();
   }
diff --git a/app/kubernetes/views/configurations/edit/configurationController.js b/app/kubernetes/views/configurations/edit/configurationController.js
index 3da73e396..50cd65d37 100644
--- a/app/kubernetes/views/configurations/edit/configurationController.js
+++ b/app/kubernetes/views/configurations/edit/configurationController.js
@@ -204,6 +204,23 @@ class KubernetesConfigurationController {
     return this.$async(this.getConfigurationsAsync);
   }
 
+  tagUsedDataKeys() {
+    const configName = this.$transition$.params().name;
+    const usedDataKeys = _.uniq(
+      this.configuration.Applications.flatMap((app) =>
+        app.Env.filter((e) => e.valueFrom && e.valueFrom.configMapKeyRef && e.valueFrom.configMapKeyRef.name === configName).map((e) => e.name)
+      )
+    );
+
+    this.formValues.Data = this.formValues.Data.map((variable) => {
+      if (!usedDataKeys.includes(variable.Key)) {
+        return variable;
+      }
+
+      return { ...variable, Used: true };
+    });
+  }
+
   async onInit() {
     try {
       this.state = {
@@ -228,6 +245,8 @@ class KubernetesConfigurationController {
       await this.getApplications(this.configuration.Namespace);
       await this.getEvents(this.configuration.Namespace);
       await this.getConfigurations();
+
+      this.tagUsedDataKeys();
     } catch (err) {
       this.Notifications.error('Failure', err, 'Unable to load view data');
     } finally {