diff --git a/go.mod b/go.mod
index d6f9db7d43..5b4fb1bdad 100644
--- a/go.mod
+++ b/go.mod
@@ -5,6 +5,7 @@ go 1.16
 replace (
 	github.com/Microsoft/hcsshim => github.com/Microsoft/hcsshim v0.8.20
 	github.com/benmoss/go-powershell => github.com/k3s-io/go-powershell v0.0.0-20201118222746-51f4c451fbd7
+	github.com/cloudnativelabs/kube-router => github.com/k3s-io/kube-router v1.3.3-0.20220405142336-8ea9a06dc0e3
 	github.com/containerd/aufs => github.com/containerd/aufs v1.0.0
 	github.com/containerd/btrfs => github.com/containerd/btrfs v1.0.0
 	github.com/containerd/cgroups => github.com/containerd/cgroups v1.0.1
@@ -76,6 +77,7 @@ require (
 	github.com/containerd/fuse-overlayfs-snapshotter v1.0.2
 	github.com/containerd/go-cni v1.0.2 // indirect
 	github.com/containerd/imgcrypt v1.1.1 // indirect
+	github.com/coreos/go-iptables v0.6.0
 	github.com/coreos/go-systemd v0.0.0-20190719114852-fd7a80b32e1f
 	github.com/docker/docker v20.10.10+incompatible
 	github.com/erikdubbelboer/gspt v0.0.0-20190125194910-e68493906b83
diff --git a/go.sum b/go.sum
index 96dd05f67c..03d4183635 100644
--- a/go.sum
+++ b/go.sum
@@ -166,8 +166,6 @@ github.com/cilium/ebpf v0.5.0/go.mod h1:4tRaxcgiL706VnOzHOdBlY8IEAIdxINsQBcU4xJJ
 github.com/cilium/ebpf v0.6.2/go.mod h1:4tRaxcgiL706VnOzHOdBlY8IEAIdxINsQBcU4xJJXRs=
 github.com/cilium/ebpf v0.7.0 h1:1k/q3ATgxSXRdrmPfH8d7YK0GfqVsEKZAX9dQZvs56k=
 github.com/cilium/ebpf v0.7.0/go.mod h1:/oI2+1shJiTGAMgl6/RgJr36Eo1jzrRcAWbcXO2usCA=
-github.com/cloudnativelabs/kube-router v1.3.2 h1:OBnFEP8IIIiWDAWd25QXDtyXDQi6GxR0DHOP+EXcpNI=
-github.com/cloudnativelabs/kube-router v1.3.2/go.mod h1:bu7wbMiNX44Rx7mSCcvgNot2jVHuaBDu/z5ygcEtAJY=
 github.com/clusterhq/flocker-go v0.0.0-20160920122132-2b8b7259d313/go.mod h1:P1wt9Z3DP8O6W3rvwCt0REIlshg1InHImaLW0t3ObY0=
 github.com/cockroachdb/datadriven v0.0.0-20190809214429-80d97fb3cbaa h1:OaNxuTZr7kxeODyLWsRMC+OD03aFUH+mW6r2d+MWa5Y=
 github.com/cockroachdb/datadriven v0.0.0-20190809214429-80d97fb3cbaa/go.mod h1:zn76sxSg3SzpJ0PPJaLDCu+Bu0Lg3sKTORVIj19EIF8=
@@ -605,6 +603,8 @@ github.com/k3s-io/helm-controller v0.10.8 h1:O7zoqUBp3W+6+nRCUWNiAoQMzOX6xw9IsBD
 github.com/k3s-io/helm-controller v0.10.8/go.mod h1:nZP8FH3KZrNNUf5r+SwwiMR63HS6lxdHdpHijgPfF74=
 github.com/k3s-io/kine v0.6.5 h1:gYjkuVUUhuIMthIAQSecb2APSx+JZLFO/GWHbDp2NFI=
 github.com/k3s-io/kine v0.6.5/go.mod h1:+QI+2dFYzFaFEdhXz3jFcY5HoD0SNXtMI22SxYhD7jk=
+github.com/k3s-io/kube-router v1.3.3-0.20220405142336-8ea9a06dc0e3 h1:Fm8ZV0dgaoCGshnwWhRgnyWVfFtdVYar+sYU5Ne67fk=
+github.com/k3s-io/kube-router v1.3.3-0.20220405142336-8ea9a06dc0e3/go.mod h1:sxZiFDEBgbjXM3SHhxJpV3701TuWIXN+JIQd5k9bDls=
 github.com/k3s-io/kubernetes v1.21.11-k3s1 h1:2g5/U2r3bBnbaGBmaNAiTqsnKa8miYwQPht6dEOctqU=
 github.com/k3s-io/kubernetes v1.21.11-k3s1/go.mod h1:VzjrpoDvaMSp8HqvFjmXEC0tzTuxHLxitfANe2YztP8=
 github.com/k3s-io/kubernetes/staging/src/k8s.io/api v1.21.11-k3s1 h1:ANAWKjEp02M1Lp8LvWtepu7oLlXJbzva1LAhVGsdbro=
diff --git a/pkg/agent/netpol/netpol.go b/pkg/agent/netpol/netpol.go
index 6df0e727ce..59e7490933 100644
--- a/pkg/agent/netpol/netpol.go
+++ b/pkg/agent/netpol/netpol.go
@@ -15,8 +15,12 @@ import (
 	"github.com/cloudnativelabs/kube-router/pkg/healthcheck"
 	"github.com/cloudnativelabs/kube-router/pkg/options"
 	"github.com/cloudnativelabs/kube-router/pkg/utils"
+	"github.com/coreos/go-iptables/iptables"
+	"github.com/pkg/errors"
 	"github.com/rancher/k3s/pkg/daemons/config"
+	"github.com/rancher/k3s/pkg/util"
 	"github.com/sirupsen/logrus"
+	v1core "k8s.io/api/core/v1"
 	"k8s.io/client-go/informers"
 	"k8s.io/client-go/kubernetes"
 	"k8s.io/client-go/tools/clientcmd"
@@ -50,7 +54,9 @@ func Run(ctx context.Context, nodeConfig *config.Node) error {
 	}
 
 	krConfig := options.NewKubeRouterConfig()
-	krConfig.ClusterIPCIDR = nodeConfig.AgentConfig.ServiceCIDR.String()
+	krConfig.ClusterIPCIDR = util.JoinIPNets(nodeConfig.AgentConfig.ServiceCIDRs)
+	krConfig.EnableIPv4 = true
+	krConfig.EnableIPv6 = nodeConfig.AgentConfig.EnableIPv6
 	krConfig.NodePortRange = strings.ReplaceAll(nodeConfig.AgentConfig.ServiceNodePortRange.String(), "-", ":")
 	krConfig.HostnameOverride = nodeConfig.AgentConfig.NodeName
 	krConfig.MetricsEnabled = false
@@ -71,6 +77,35 @@ func Run(ctx context.Context, nodeConfig *config.Node) error {
 	informerFactory.Start(stopCh)
 	informerFactory.WaitForCacheSync(stopCh)
 
+	iptablesCmdHandlers := make(map[v1core.IPFamily]utils.IPTablesHandler, 2)
+	ipSetHandlers := make(map[v1core.IPFamily]utils.IPSetHandler, 2)
+
+	iptHandler, err := iptables.NewWithProtocol(iptables.ProtocolIPv4)
+	if err != nil {
+		return errors.Wrap(err, "failed to create iptables handler")
+	}
+	iptablesCmdHandlers[v1core.IPv4Protocol] = iptHandler
+
+	ipset, err := utils.NewIPSet(false)
+	if err != nil {
+		return errors.Wrap(err, "failed to create ipset handler")
+	}
+	ipSetHandlers[v1core.IPv4Protocol] = ipset
+
+	if nodeConfig.AgentConfig.EnableIPv6 {
+		ipt6Handler, err := iptables.NewWithProtocol(iptables.ProtocolIPv6)
+		if err != nil {
+			return errors.Wrap(err, "failed to create iptables handler")
+		}
+		iptablesCmdHandlers[v1core.IPv6Protocol] = ipt6Handler
+
+		ipset, err := utils.NewIPSet(true)
+		if err != nil {
+			return errors.Wrap(err, "failed to create ipset handler")
+		}
+		ipSetHandlers[v1core.IPv6Protocol] = ipset
+	}
+
 	// Start kube-router healthcheck server. Netpol requires it
 	hc, err := healthcheck.NewHealthController(krConfig)
 	if err != nil {
@@ -83,7 +118,8 @@ func Run(ctx context.Context, nodeConfig *config.Node) error {
 	wg.Add(1)
 	go hc.RunCheck(healthCh, stopCh, &wg)
 
-	npc, err := netpol.NewNetworkPolicyController(client, krConfig, podInformer, npInformer, nsInformer, &sync.Mutex{})
+	npc, err := netpol.NewNetworkPolicyController(client, krConfig, podInformer, npInformer, nsInformer, &sync.Mutex{},
+		iptablesCmdHandlers, ipSetHandlers)
 	if err != nil {
 		return err
 	}
diff --git a/pkg/cli/server/server.go b/pkg/cli/server/server.go
index d38480950a..441a763e8c 100644
--- a/pkg/cli/server/server.go
+++ b/pkg/cli/server/server.go
@@ -499,22 +499,11 @@ func validateNetworkConfiguration(serverConfig server.Config) error {
 	// Dual-stack operation requires fairly extensive manual configuration at the moment - do some
 	// preflight checks to make sure that the user isn't trying to use flannel/npc, or trying to
 	// enable dual-stack DNS (which we don't currently support since it's not easy to template)
-	dualCluster, err := utilsnet.IsDualStackCIDRs(serverConfig.ControlConfig.ClusterIPRanges)
-	if err != nil {
-		return errors.Wrap(err, "failed to validate cluster-cidr")
-	}
-	dualService, err := utilsnet.IsDualStackCIDRs(serverConfig.ControlConfig.ServiceIPRanges)
-	if err != nil {
-		return errors.Wrap(err, "failed to validate service-cidr")
-	}
 	dualDNS, err := utilsnet.IsDualStackIPs(serverConfig.ControlConfig.ClusterDNSs)
 	if err != nil {
 		return errors.Wrap(err, "failed to validate cluster-dns")
 	}
 
-	if (serverConfig.ControlConfig.DisableNPC == false) && (dualCluster || dualService) {
-		return errors.New("network policy enforcement is not compatible with dual-stack operation; server must be restarted with --disable-network-policy")
-	}
 	if dualDNS == true {
 		return errors.New("dual-stack cluster-dns is not supported")
 	}